上海丰核信息科技有限公司同中国科学院上海生命科学研究院生物化学与细胞生物学研究所季红斌研究组合作开发的一个肺癌相关基因、蛋白以及小分子RNA的信息库平台（http://www.megabionet.org/bio/hlung）发表在影响因子为7.479分的《Nucleic Acids Research》杂志。

文章链接: http://www.ncbi.nlm.nih.gov/pubmed/19900972 

上海丰核信息科技有限公司同季红斌研究组与合作，分析了271个肺癌样本的表达谱数据，同时结合文献数据的人工挖掘，建立了一个整合肺癌相关基因、蛋白（主要是转录因子）以及小分子RNA的信息平台。该平台目前包括在肺癌发生发展不同阶段起作用的2585个基因和212个小分子RNA，并整合其启动子区域分析、表观遗传学改变和SNP位点分析。此外，该平台还包括在肺癌发病过程中一些重要的信号通路。用户可以直接通过平台链接浏览与肺癌相关的基因、小分子RNA、SNP位点、甲基化以及信号通路等等。这一肺癌相关信息平台的建立不仅有助于对某些特定的分子或生物学标记物进行深入的了解，而且为系统性地研究肺癌发病相关的分子机理奠定了坚实的基础。

Abstract

The human lung cancer database (HLungDB) is a database with the integration of the lung cancer-related genes, proteins and miRNAs together with the corresponding clinical information. The main purpose of this platform is to establish a network of lung cancer-related molecules and to facilitate the mechanistic study of lung carcinogenesis. The entries describing the relationships between molecules and human lung cancer in the current release were extracted manually from literatures. Currently, we have collected 2585 genes and 212 miRNA with the experimental evidences involved in the different stages of lung carcinogenesis through text mining. Furthermore, we have incorporated the results from analysis of transcription factor-binding motifs, the promoters and the SNP sites for each gene. Since epigenetic alterations also play an important role in lung carcinogenesis, genes with epigenetic regulation were also included. We hope HLungDB will enrich our knowledge about lung cancer biology and eventually lead to the development of novel therapeutic strategies. HLungDB can be freely accessed at http://www.megabionet.org/bio/hlung.

HLungDB: an integrated database of human lung cancer research Nucleic Acids research, (2010) Volume 38 Issue 17 SCI影响因子：7.479